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ANGIOEDEMA

Hereditary angioedema (HAE) is a rare disease, affecting about 1 in 50,000 people worldwide, and presents unique challenges for those who suffer from it. Patients rely on your guidance to manage these sudden attacks of swelling and to help prevent future ones. If you have a patient with HAE, now is the time to explore strategies to support them.1‑3

Discover the cause
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What is HAE?

HAE is a rare, genetic disease that brings unpredictable, recurrent attacks of painful swelling, which can be life‑threatening.

Characterized by recurrent, unpredictable swelling attacks without itching, HAE attacks can cause intense pain and functional limitations. Swelling often occurs in areas like the face, hands, feet, abdomen, and genitals, but attacks in the throat can be life-threatening due to airway obstruction. These attacks stem from a deficiency or dysfunction of C1 esterase inhibitor (C1-INH), leading to excess bradykinin production and uncontrolled swelling.1,3,4

Discover the symptoms
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How can HAE impact patients?

Living with HAE can disrupt every part of a patient's life, with frequent, unpredictable attacks limiting daily activities and social engagement. As a healthcare provider, your proactive support can make a real difference. Encourage open conversations to develop a plan that helps patients manage their HAE.5

Discover the impact
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How can HAE be managed?

Effective HAE management relies on a strong provider-patient partnership. Together, you can create a plan that fits each patients' needs.

Discover management options
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References:

  1. Longhurst HJ, Bork K. Hereditary angioedema: causes, manifestations and treatment. Br J Hosp Med (Lond). 2006;67(12):654-657.
  2. Bork K, Meng G, Staubach P, Hardt J. Hereditary angioedema: new findings concerning symptoms, affected organs, and course. Am J Med. 2006;119(3):267-274.
  3. Zuraw BL. Clinical practice. Hereditary angioedema. N Engl J Med. 2008;359(10):1027-1036
  4. Busse PJ, Christiansen SC, Riedl MA, et al. US HAEA Medical Advisory Board 2020 guidelines for the management of hereditary angioedema. J Allergy Clin Immunol Pract. 2021;9(1):132-150. doi:10.1016/j.jaip.2020.08.046
  5. Longhurst HJ, Bork K. Hereditary angioedema: an update on causes, manifestations and treatment. Br J Hosp Med (Lond). 2019;80(7):391-398. doi:10.12968/hmed.2019.80.7.391